Metabolic Maintenance Same + CoFactors

Price: $73.00
(as of Mar 17, 2026 13:24:45 UTC – Details)


Supports mood, liver, and methylation health through synergistic nutrient support.*
What It Does
SAMe with Cofactors provides targeted nutritional support for balanced mood, healthy liver function, and optimal methylation activity.* This comprehensive formula combines S-adenosyl-L-methionine (SAMe) with essential methyl donors and cofactors—vitamin B6, active folate, and methylcobalamin to help sustain neurotransmitter synthesis, cellular detoxification, and energy metabolism.*
How It Works
SAMe (S-adenosyl-L-methionine) — Serves as a universal methyl donor that supports serotonin, dopamine, and norepinephrine metabolism while promoting liver detoxification and phospholipid synthesis.* [1,2]
L-5-Methylfolate — Provides the biologically active form of folate, essential for the remethylation of homocysteine and production of neurotransmitters involved in mood regulation.* [3,4]
Vitamin B12 (as methylcobalamin) — Works with folate and SAMe to maintain methylation balance, support nerve integrity, and aid in red blood cell formation.* [4,5]
Vitamin B6 (as pyridoxal-5′-phosphate) — Functions as a coenzyme in amino acid metabolism and assists in the synthesis of serotonin, GABA, and dopamine.* [5]
Who It’s For
Ideal for individuals seeking support for mood balance, cognitive clarity, and liver function, or those with increased methylation demands due to stress, genetic polymorphisms, or other situations.*
Special Features
Features the active, bioavailable forms of B-vitamins including methylcobalamin, L-5-MTHF, and P-5-P for immediate utilization, with 400 mg of SAMe to optimize methylation efficiency. Free of gluten, soy, and artificial excipients, and manufactured under strict quality standards for purity and strength.*

Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 4 x 2.15 x 2.15 inches; 6.4 ounces
Department ‏ : ‎ Adults
Date First Available ‏ : ‎ June 20, 2017
Manufacturer ‏ : ‎ Metabolic Maintenance
ASIN ‏ : ‎ B072YWJNTT
Best Sellers Rank: #206,861 in Health & Household (See Top 100 in Health & Household) #2,393 in Amino Acid Nutritional Supplements
Customer Reviews: 4.1 4.1 out of 5 stars (23) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Cognitive Benefits – Our Sam-E Supplements can help support a balanced mood, promote normal brain health, and nourish healthy neurotransmitter formation. This once daily formula provides SAMe 200mg per serving.*
Shelf-Stable Support – Cofactors like methylated folate, Magnesium, B12 and B6 vitamins support optimal methylation. Calcium citrate also ensures our SAMe supplements are less sensitive to humidity and temperature — and don’t have to be refrigerated.*
Heart + Joint Health – Sam e assists the conversion of homocysteine back to SAMe, to help protect your arteries. It may also promote healthy Joint Support and liver health.*
Supports Methylation With Cofactors – Provides 200 Mg Same With Active Cofactors B6, B12, And Methylfolate To Help Support Healthy Methylation Pathways In The Body*
Pure Potency – Each Two-Capsule Serving Delivers A Full 200Mg Of Active Adenosylmethionine, Free From Preservatives, Artificial Additives, Gluten, Egg, Or Nuts*